Spinach RNA aptamer detects lead(II) with high selectivity.
نویسندگان
چکیده
Spinach RNA aptamer contains a G-quadruplex motif that serves as a platform for binding and fluorescence activation of a GFP-like fluorophore. Here we show that Pb(2+) induces formation of Spinach's G-quadruplex and activates fluorescence with high selectivity and sensitivity. This device establishes the first example of an RNA-based sensor that provides a simple and inexpensive tool for Pb(2+) detection.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 43 شماره
صفحات -
تاریخ انتشار 2015